Complete list of publications can be found here.
2021
Cuevas-Navarro, A., Van, R., Cheng, A., Urisman, A., Castel, P., McCormick, F. 2021. The RAS GTPase RIT1 compromises mitotic fidelity through spindle assembly checkpoint suppression. Curr Biol 31, 1-10. https://doi.org/10.1016/j.cub.2021.06.030
Whiteaker, J.R., Sharma, K., Hoffman, M.A., Kuhn, E., Zhao, L., Cocco, A.R., Schoenherr, R.M., Kennedy, J.J., Voytovich, U., Lin, C., Fang, B., Bowers, K., Whiteley, G., Colantonio, S., Bocik, W., Robers, R., Hiltke, T., Boja, E., Rodriguez, H., McCormick, F., Holderfield, M., Carr, S.A., Koomen, J.M., and Paulovich, A.G. 2021. Targeted mass-spectrometry-based assays enable multiplex quantification of receptor tyrosine kinase, MAP kinase, and AKT signaling. Cell Reports Methods https://doi.org/10.1016/j.crmeth.2021.100015.
Okutachi, S., Manoharan, G.B., Kiriazis, A., Laurini, C., Catillon, M., McCormick, F., Yli-Kauhaluoma, J., and Abankwa, D. 2021. A covalent calmodulin inhibitor as a tool to study cellular mechanisms of K-Ras-driven stemness. Front. Cell Dev. Biol. doi: 10.3389/fcell.2021.665673
Inoue, D., Polaski, J.T., Taylor, J., Castel, P., Chen, S., Kobayashi, S., Hogg, S.J., Hayashi, Y., Bello Pineda, J.M., El Marabti, E., Erickson, C., Knorr, K., Fukumoto, M., Yamazaki, H., Tanaka, A., Fukui, C., Lu, S.X., Durham, B.H., Liu, B., Wang, E., Mehta, S., Zakheim, D., Garippa, R., Penson, A., Chew, G.L., McCormick, F., Bradley, R.K., and Abdel-Wahab, O. 2021. Minor intron retention drives clonal hematopoietic disorders and diverse cancer predisposition. Nat Genet 53, 707–718. https://doi.org/10.1038/s41588-021-00828-9
Lai, L.P., Brel, V., Sharma, K., Frappier, J., Le-Henanf, N., Vivet, B., Muzet, N., Schell, E., Morales, R., Rooney, E., Basse, N., Yi, M., Lacroix, F., Holderfield, M., Englaro, W., Marcireau, C., Debussche, L., Nissley, D.V., McCormick, F. 2021. Sensitivity of Oncogenic KRAS-Expressing Cells to CDK9 Inhibition. SLAS Discov. doi: 10.1177/24725552211008853. Online ahead of print.PMID: 33896272
Mukhopadhyay, S., Vander Heiden, M.G. and McCormick, F. 2021. The metabolic landscape of RAS-driven cancers from biology to therapy. Nat Cancer 2, 271–283. https://doi.org/10.1038/s43018-021-00184-x
Moore, A.R., Rosenberg, S.C., McCormick., F., Malek, S. 2021. RAS-targeted therapies. (Poster) Nat Rev Drug Discov. doi: 10.1038/s41573-021-00220-6. Online ahead of print.PMID: 33990767
Tran, T.H., Chan, A.H., Young, L.C., Bindu, L., Neale, C., Messing, S., Dharmaiah, S., Taylor, T., Denson, JP., Esposito, D., Nissley, D.V., Stephen, A.G., McCormick, F., Simanshu, D.K. 2021. KRAS interaction with RAF1 RAS-binding domainand cysteine-rich domain provides insights into RAS-mediated RAF activation. Nat Commun 12:1176. https://doi.org/10.1038/s41467-021-21422-x
2020
Lorenzo, C. and McCormick, F. 2020. SPRED proteins and their roles in signal transduction, development, and malignancy. Genes & Dev. 34: 1410-1421. doi: 10.1101/gad.341222.120.
Castel. P., Holtz-Morris, A., Kwon, Y., Suter, B.P., McCormick, F., 2020. DoMY-Seq: A yeast two-hybrid-based technique for precision mapping of protein-protein interaction motifs. J Biol Chem 23:296:100023. doi: 10.1074/jbc.RA120.014284.
Cuevas-Navarro, A., Van, R., Cheng, A., Urisman, A., Castel, P., McCormick, F. 2020. The RAS GTPase RIT1 compromises mitotic fidelity through spindle assembly checkpoint suppression. bioRxiv. doi: https://doi.org/10.1101/2020.11.17.386177.
Gillies, T.E., Pargett, M., Silva, J.M., Teragawa, C.K., McCormick, F., Albeck, J.G. 2020. Oncogenic mutant RAS signaling activity is rescaled by the ERK/MAPK pathway. Mol Syst Biol. (10):e9518. doi: 10.15252/msb.20209518.PMID: 33073539
Wolfe, A., Zhou, Q., Toska, E., Galeas, G., Ku, A.A., Koche, R.P., Bandyopadhyay, S., Scaltriti, M., Lebrilla, C.B., McCormick, F., Kim, S.E. 2020. UDP-glucose pyrophosphorylase 2, a regulator of glycosylation and glycogen, is essential for pancreatic cancer growth. bioRxiv. doi: https://doi.org/10.1101/2020.11.17.386177.
Van QN, López CA, Tonelli M, Taylor T, Niu B, Stanley CB, Bhowmik D, Tran TH, Frank PH, Messing S, Alexander P, Scott D, Ye X, Drew M, Chertov O, Lösche M, Ramanathan A, Gross ML, Hengartner NW, Westler WM, Markley JL, Simanshu DK, Nissley DV, Gillette WK, Esposito D, McCormick F, Gnanakaran S, Heinrich F, Stephen AG. 2020. Uncovering a membrane-distal conformation of KRAS available to recruit RAF to the plasma membrane. Proc Natl Acad Sci U S A 117(39):24258-24268. doi: 10.1073/pnas.2006504117.
Castel, P., Rauen, K.A., McCormick, F. 2020. The duality of human oncoproteins: drivers of cancer and congenital disorder. Nat Rev Cancer Jul;20(7):383-397. doi: 10.1038/s41568-020-0256-z.
Van, R., Cuevas-Navarro, A., Castel, P., McCormick, F. 2020. The molecular functions of RIT1 and its contribution to human disease. Biochem J 14 August 2020; 477 (15): 2755–2770. doi: https://doi.org/10.1042/BCJ20200442
Yan, W., Markegard, E., Dharmaiah, S., Urisman, A., Drew, M., Esposito, D., Scheffzek, K., Nissley, D.V., McCormick, F., Simanshu, D.K. 2020. Structural Insights into the SPRED1-Neurofibromin-KRAS Complex and Disruption of SPRED1-Neurofibromin Interaction by Oncogenic EGFR. Cell Rep. Jul 21;32(3):107909. doi: 10.1016/j.celrep.2020.107909.
McCormick, F. 2020. Sticking it to KRAS: Covalent inhibitors enter the clinic. Cancer Cell. https://doi.org/10.1016/j.ccell.2019.12.009
Donohue E, Khorsand S, Mercado G, Varney KM, Wilder PT, Yu W, MacKerell AD Jr, Alexander P, Van QN, Moree B, Stephen AG, Weber DJ, Salafsky J, McCormick F. 2020. Second harmonic generation detection of Ras conformational changes and discovery of a small molecule binder. Proc Natl Acad Sci U S A (35):17290-17297. doi: 10.1073/pnas.1905516116. Epub 2019 Aug 9.
Mukhopadhyay, S., Goswami, D., Adiseshaiah, PP., Burgan, W., Yi, M., Guerin, TM., Kozlov, SV., Nissley, DV., McCormick, F. 2020. Undermining glutaminolysis bolsters chemotherapy while NRF2 promotes chemoresistance in KRAS-driven pancreatic cancers. Cancer Research. DOI: 10.1158/0008-5472.
Wu, C.H., Yang, C.Y., Wang, L., Gao, H.X., Rakhshandehroo, T., Afghani, S., Pincus, L., Balassanian, R., Rubenstein, J., Gill, R., Bandyopadhyay, S., McCormick, F., Moasser, M., Weiyun, W.Z. 2020. Cutaneous T cell lymphoma PDX drug screening platform identifies cooperation between inhibitions of PI3Kα/δ and HDAC. J Invest Dermatol. Jun 27;S0022-202X(20)31724-3. doi: 10.1016/j.jid.2020.05.110. Online ahead of print.
Ku, A., Hu, H.M., Zhao, X., Shah, K. N., Kongara, S., Wu, D., McCormick, F., Balmain, A., Bandyopadhyay, S. 2020. Integration of multiple biological contexts reveals principles of synthetic lethality that affect reproducibility. Nat Commun. May 12;11(1):2375. doi: 10.1038/s41467-020-16078-y.
Gross, A.M., Frone, M., Gripp, K.W., Gelb, B.D., Schoyer, L., Schill, L., Stronach, B., Biesecker, L.G., Esposito, D., Hernandez, E.R., Legius, E., Loh, M.L., Martin, S., Morrison, D.K., Rauen, K.A., Wolters, P.L., Zand, D., McCormick, F., Savage, S.A., Stewart, D.R., Widemann, B.C., Yohe, M.E. 2020. Advancing RAS/RASopathy therapies: An NCI-sponsored intramural and extramural collaboration for the study of RASopathies. Am J Med Genet Apr;182(4):866-876. doi: 10.1002/ajmg.a.61485. Epub 2020 Jan 8. https://pubmed.ncbi.nlm.nih.gov/31913576/
Goswami, D., Cheng, Yang Y., Gudla, P.R., Columbus, J., Worthy, K., Rigby, M., Wheeler, M., Mukhopadhyay, S., Powell, K., Burgan, W., Wall, V., Esposito, D., Lightstone, F.C., Nissley, D.V., McCormick, F., Turbyville, T. 2020. Membrane interactions of the globular domain and the hypervariable region of KRAS4b define its unique diffusion behavior. Elife Jan 20;9:e47654. doi: 10.7554/eLife.47654. https://pubmed.ncbi.nlm.nih.gov/31958057/
Tran, T.H., Alexander, P., Dharmaiah, S., Agamasu, C., Nissley, D.V., McCormick, F., Esposito, D.,vSimanshu, D.K., Stephen, A.G., Balius, T.E. 2020. The small molecule BI2852 induces a nonfunctional dimer of KRAS. Proc Natl Acad Sci U S A. Feb18;117(7):3363-3364. doi: 10.1073/pnas.1918164117. Epub 2020 Feb 11. https://pubmed.ncbi.nlm.nih.gov/32047043/
Li, YC., Lytlea, N., Gammon, S.T., Wanga, L., Hayesc, T.K., Sutton, M.N., Bast Jr.,R.C., Der, C., Piwnica-Worms, D., McCormick, F., Wahl, G.M. 2020. Analysis of RAS protein interactions in living cells reveals a mechanism for pan-RAS depletion by membrane targeted RAS binders. Proc Natl Acad Sci U S A. June 2: 117 (22) 12121-12130; https://pubmed.ncbi.nlm.nih.gov/32424096/
Moore, A.R., Rosenberg, S.C., McCormick, F., Malek, S. 2020. RAS-targeted Therapies: Is the Undruggable Drugged? Nat Rev Drug Discov. Online ahead of print. 2020 Jun 11. doi:10.1038/s41573020-0068-6. https://pubmed.ncbi.nlm.nih.gov/32528145/
Yi, M., Nissley, D.V., McCormick, F., Stephens, R.M. 2020. ssGSEA Score-Based Ras Dependency Indexes Derived From Gene Expression Data Reveal Potential Ras Addiction Mechanisms With Possible Clinical Implications. Sci Rep. Jun24;10(1):10258.
doi: 10.1038/s41598-020-669868. https://pubmed.ncbi.nlm.nih.gov/32581224/
2019
Sherekar, M., Han, SW., Ghirland, R., Messing, S., Drew, M., Rabara, D., Waybright, T., Juneja, P., O'Neill, H., Stanley, CB., Bhowmik, D., Ramanathan, Ar., Subrimaniam, S., Nissley, DV., Gillette, W., McCormick, F., Esposito, D. 2019. Biochemical and structural analyses reveal that the tumor suppressor neurofibromin (NF1) forms a high-affinity dimer. Journal of biological Chemistry. doi: 10.1074/jbc.RA119.010934
Wang, VE., Xue, JY., Frederick, DT., Cao, Y., Lin, E., Wilson, C., Urisman, A., Carbone, DP., Flaherty, KT., Bernards, R., Lito, P., Settleman, J., McCormick, F. 2019. Adaptive resistance to dual BRAF/MEK inhibition in BRAF-driven tumors through autocrine FGFR pathway activation. Clinical Cancer Research. DOI: 10.1158/1078-0432.CCR-18-2779
Rabara, D., Tran, T.H., Dharmaiah, S., Stephens, R.M., McCormick. F., Simanshu, D.K., Holderfield, M. 2020. KRAS G13D sensitivity to neurofibromin-mediated GTP hydrolysis. Proc Natl Acad Sci U S A. 116(44):22122-22131. doi: 10.1073/pnas.1908353116. Epub 2019 Oct 14.
Wang, MT., Fer, N., Galeas, J., Collison, EA., Kim, SE., Sharib, J., McCormick, F. 2019. Blockade of leukemia inhibitory factor as a therapeutic approach to KRAS driven pancreatic cancer. Nature communications. https://doi.org/10.1038/s41467-019-11044-9
Bai, R.Y., Esposito, D., Tam, A.J., McCormick, F., Riggins, G.J., Clapp Wade, D., Staedke, V. 2019. Feasibility of using NF1-GRD and AAV for gene replacement therapy in NF1-associate tumors. Gene Therapy. doi:10.1038/s41434-019-0080-9
Agamasu, C., Ghirlando, R., Taylor, T., Messing, S., Tran, T.H., Bindu, L., Tonelli, M., Nissley, D.V., McCormick, F., Stephan, A.G., 2019. KRAS prenylation is required for bivalent binding with Calmodulin in a nucleotide-independent manner. Biophysical Journal 116 (6) 1049-1063. https://doi.org/10.1016/j.bpj.2019.02.004
Castel, P., Cheng, A., Cuevas-Navarro, A., Everman, D.B., Papageorge, A.G. Simanshu, D.K., Tankka, A., Galeas, J., Urisman, A., McCormick, F. 2019. RIT1 oncoproteins escape LTZR1-mediated proteolysis. Science 363(6432) 1226-1230. DOI: 10.1126/science.aav1444
Lee, C.S., Lee, L.C., Yuan, T.L., Chakka, S., Fellmann, C., Lowe S.W., Caplen, N.J., McCormick, F., Luo, J. 2019. MAP kinase and autophagy pathways cooperate to maintain RAS mutant cancer cell survival. PNAS 116(10) 4508-4517. www.pnas.org/cgi/doi/10.1073/pnas.1817494116
Lakshman, B., Messing, S., Schmid, E.M., Clogston, J.D., Gillette, W.K., Esposito, D., Kessing, B., Fletcher, D.A., Nissley, D.V., McCormick, F., Stephan, A.G., Jean-Francois, F.L. 2019. Quantitative biophysical analysis defines key components modulating recruitment of GTPase KRAS to the plasma membrane. Journal of Biological Chemistry 294(6) 2193-2207. doi:10.1074/jbc.RA118.005669
McCormick, F. 2019. Progress in targeting RAS with small molecule drugs. Biochemical Journal. 476 365-374. https://doi.org/10.1042/BCJ20170441
Ku, A.A., Kongara, S., Hu, H.M., Zhao, X., Wu, D., McCormick, F., Balmain, A., Bandyopadhyay, S. 2019. Integration of pathway, cellular and genetic context reveals principles of synthetic lethality that affect reproducibility. bioRx, 591677
Shah, K.N., Bhatt, R., Rotow, J., Rohrberg, J., Olivas, V., Wang, V.E., Hemmati, G., Martins, M.M., Maynard, A., Kuhn, J., Galeas, J., Donnella, H.J., Kaushik, S., Ku, A., Dumont, S., Krings, G., Haringsma, H.J., Robillard, L., Simmons, A.D., Harding, T.C., McCormick, F., Goga, A., Blakely, C.M., Bivona, T.G., Bandyopadhyay, S. 2019. Aurora kinase A drives the evoluation of resistance to third-generation EGFR inhibitors in lung cancer. Nature Medicine 25 (1) 111-118. https://doi.org/10.1038/s41591-018-0264-7
2018
Young, L.C., Hartig, N., del Rio, I.B., Sari, S., Ringham-Terry, B., Wainwright, J.R., Jones, G.G., McCormick, F. Rodriguez-Viciana, P. 2019. SHOC2-MRAS-PP1 complex positively regulates RAF activity anf contributes to Noonan syndrome pathogenesis. PNAS 115(45), E10676-E10585. www.pnas.org/cgi/doi/10.1073/pnas.1720352115
Ye, X., Luke, B.T., Wei, B.R., Kaczmarczyk, J.A., Loncarek, J., Dwyer, J.E., Johann, D.J., Saul, R.G., Nissley, D.V., McCormick, F., Whiteley, G.R., Blonder, J. 2018. Direct molecular dissection of tumor parenchyma from tumor stroma in tumor xenograft using mass spectrometry-based glycoproteomics. Oncotarget 9(41) 26431. doi:10.18632/oncotarget.25449
McCormick, F. 2018. Targeting KRAS directly. Annual Review of Cancer Biolohy 2, 81-90. doi: 10.1146/annurev-cancerbio-050216-122010
Yuan, T.L. Amzallag, A., Bagni, R., Yi, M., Afghani, S., Burga, W., Fer, N., Strather, L.A., Powell, K., Smith, B., Waters, A.M., Drubin, D., Thomson, T., Liao, R., Greninger, P., Stein, G.T., Murchie, E., Cortez, E., Egan, R.K., Procter, L., Bess, M., Cheng, K.T., Lee, C.S., Lee, L.C., Fellman, C., Stephens, R., Luo, J., Lowe, S.W., Benes, C.H., McCormick, F. 2018. Differential effector engagement by oncogenic KRAS. Cell Reports 22(7) 1889-1902. doi:10.1016/j.celrep.2018.01.051
McCormick, F. 2018. c-Raf in K-Ras Mutant Cancers: A Moving Target. 2018. Cancer cell 33(2), 158-159. doi: 10.1016/j.ccell.2018.01.017
Boettcher, M., Tian, R., Blau, J.A., Markegard, E., Wagner, R.T., Wu, D., Mo, X., Biton, A., Zaitlen, N., Fu, H., McCormick, F., Kampmann, M., McManus, M.T. 2018. Dual gene activation and knockout screen reveals directional dependencies in genetic networks. Nature Biotechnology 36(2) 170. doi: 10.1038/nbt.4062.
Van Aelst, L., Downward, J., McCormick, F. 2018. RAS and Cancer in the 21st Century. Cold Spring Harbor Labortory Press.
Li, Y.C., Wang, L., Hayes, T.K., Sutton, M.N., Bast, R.C., McCormick, F., Der, C.J., Wahl, G.M. 2018. Facile real time detection of membrane colocalization of RAS superfamily GTPase proteins in living cells. bioRxiv 369687.
2017
Kitagawa, M., Liao, P.J., Lee, K.H., Wong, J., Shang, S.C., Minami, N., Sampetrean, O., Saya, H., Lingyun, D., Prabhu, N., Diam, G.K., Sobota, R., Larsson, A., Nordlund, P., McCormick, F., Ghosh, S., Epstein, D.M., Dymock, B.W., Lee, S.H. 2017. Dual blockade of the lipid kinase PIP4Ks and mitotic pathways leads to cancer-selective lethality. Nature Communications 8(1):2200. doi: 10.1038/s41467-017-02287-5.
Hangauer MJ, Viswanathan VS, Ryan MJ, Bole D, Eaton JK, Matov A, Galeas J, Dhruv HD, Berens ME, Schreiber SL, McCormick F, McManus MT. 2017 Drug-tolerant persister cancer cells are vulnerable to GPX4 inhibition. Nature 551:247-250
Waters, A.M., Ozkan-Dagliyan, I., Vaseva, A.V., Fer, N., Strathern, L.A., Hobbs, G.A., Tessier-Cloutier, B., Gillette, W.K., Bagni, R., Whiteley, G.R., Hartley, J.L., McCormick, F., Cox, A.D., Houghton, P.J., Huntsman, D.G., Philips, M.R., Der, C.J. 2017. Evaluation of the selectivity and sensitivity of isoform- and mutation-specific RAS antibodies. Science Signaling 10 (498). doi: 10.1126/scisignal.aao3332
Tetsu O, McCormick F. 2017 ETS-targeted therapy: can it substitute for MEK inhibitors? Clinical and Translational Medicine 6:16
Simanshu DK, Nissley DV, McCormick F. 2017 RAS proteins and their regulators in human disease. Cell 170:17-33
Novotny CJ, Hamilton GL, McCormick F, Shokat KM. 2017 Farnesyltransferase-mediated delivery of a covalent inhibitor overcomes alternative prenylation to mislocalize K-Ras. ACS Chemical Biology 12:1956-1962
Stephens RM, Yi M, Kessing B, Nissley DV, McCormick F. 2017 Tumor RAS gene expression levels are influenced by the mutational status of RAS genes and both upstream and downstream RAS pathway genes. Cancer Informatics 16:1-10
Boettcher M, Tian R, Blau J, Markegard E, Wu D, Biton A, Zaitlen N, McCormick F, Kampmann M, McManus MT. 2017 Decoding directional genetic dependencies through orthogonal CRISPR/Cas screens. bioRxiv 120170
Wang SJ, Asthana S, van Zante A, Heaton CM, Phuchareon J, Stein L, Higuchi S, Kishimoto K, Chiu CY, Olshen AB, McCormick F, Tetsu O. 2017 Establishment and characterization of an oral tongue squamous cell carcinoma cell line from a never-smoking patient. Oral Oncology 69:1-10
2016
Dharmaiah S, Bindu L, Tran TH, Gillette WK, Frank PH, Ghirlando R, et al. 2016 Structural basis of recognition of farnesylated and methylated KRAS4b by PDEδ. Proc Natl Acad Sci USA 113(44):E6766-E6775. Epub 2016 Oct 17.
Gerhard DS, Clemons PA, Shamji AF, Hon C, Wagner BK, Schreiber SL, et al. 2016 Transforming big data into cancer-relevant insight: an initial, multi-tier approach to assess reproducibility and relevance. Mol Cancer Res. 14(8):675-82. doi: 10.1158/1541-7786.MCR-16-0090. Epub 2016 Jul 11.
Dunzendorfer-Matt T, Mercado EL, Maly K, McCormick F, Scheffzek K. 2016 The neurofibromin recruitment factor Spred1 binds to the GAP related domain without affecting Ras inactivation. Proc Natl Acad Sci U S A. Jun 16. pii: 201607298. [Epub ahead of print]
Tetsu O, Hangauer MJ, Phuchareon J, Eisele DW, McCormick F. 2016. Drug resistance to EGFR Inhibitors in lung cancer. Chemotherapy. 61(5):223-235. doi: 10.1159/000443368. Epub 2016 Feb 25.
Stevenson DA, Schill L, Schoyer L, Andresen BS, Bakker A, Bayrak-Toydemir P, et al. 2016. The Fourth International Symposium on Genetic Disorders of the Ras/MAPK pathway. Am J Med Genet A. 170(8):1959-66. doi: 10.1002/ajmg.a.37723. Epub 2016 May 7.
McCormick F. 2016. K-Ras protein as a drug target. J Mol Med (Berl). 94(3):253-8. doi: 10.1007/s00109-016-1382-7. Epub 2016 Mar 9.
2015
McCormick F. 2015 The potential of targeting Ras proteins in lung cancer. Expert Opin Ther Targets. 19(4):451-4. doi: 10.1517/14728222.2014.1000304. Epub 2015 Jan 6.
Martins MM, Zhou AY, Corella A, Horiuchi D, Yau C, Rakshandehroo T, Gordan JD, Levin RS, Johnson J, Jascur J, Shales M, Sorrentino A, Cheah J, Clemons PA, Shamji AF, Schreiber SL, Krogan NJ, Shokat KM, McCormick F, Goga A, Bandyopadhyay S. 2015 Linking tumor mutations to drug responses via a quantitative chemical-genetic interaction map. Cancer Discov. 5(2):154-67. doi: 10.1158/2159-8290.CD-14-0552. Epub 2014 Dec 12.
McCormick, F. 2015. KRAS as a therapeutic target. Clin Cancer Res 21(8):1797-801. doi: 10.1158/1078-0432.CCR-14-2662.
Fujita-Sato S, Galeas J, Truitt M, Pitt C, Urisman A, Bandyopadhyay S, Ruggero D, McCormick F. 2015. Enhanced MET translation and signaling sustains K-Ras driven proliferation under anchorage-independent growth conditions. Cancer Res 75:2851-62 doi: 10.1158/0008-5472.CAN-14-1623. Epub 2015 May 14
Nan X, Tamgüney, TM, Collisson EA, Lin LJ, Pitt C, Galeas J, Lewis S, Gray JW, McCormick F, Chu S. 2015. Ras-GTP dimers activate the mitogen-activated protein kinase (MAPK) pathway. Proc Natl Acad Sci U S A 112:7996-8001 doi: 10.1073/pnas.1509123112. Epub 2015 Jun 16.
Phuchareon J, McCormick F, Eisele DW, Tetsu O. 2015. EGFR inhibition evokes innate drug resistance in lung cancer cells by preventing Akt activity and thus inactivating Ets-1 function. Proc Natl Acad Sci U S A 112:E3855-63 doi: 10.1073/pnas.1510733112. Epub 2015 Jul 6.
Tetsu O, Eisele DW, McCormick F. 2015. Resistance to EGFR-targeted by Ets-1 inactivation. Cell Cycle 14:3211-2. doi: 10.1080/15384101.2015.1086200.
Gillette WK, Esposito D, Abreu Blanco M, Alexander P, Bindu L, Bittner C, et al. 2015. Farnesylated and methylated KRAS4b: high yield production of protein suitable for biophysical studies of prenylated protein-lipid interactions. Sci Rep. 5:15916. doi: 10.1038/srep15916.
Wang MT, Holderfield M, Galeas J, Delrosario R, To MD, Balmain A, McCormick F. 2015. K-Ras promotes tumorigenicity through suppression of non-canonical Wnt signaling. Cell 163 :1237-51. doi: 10.1016/j.cell.2015.10.041.
Tetsu O, Phuchareon J, Eisele DW, Hangauer MJ, McCormick F. 2015. AKT inactivation causes persistent drug tolerance to EGFR inhibitors. Pharmacol Res. 102:132-7. doi: 10.1016/j.phrs.2015.09.022. Epub 2015 Oct 22.
2014
Phuchareon J, Overdevest JB, McCormick F, Eisele DW, van Zante A, Tetsu O. 2014 Fatty Acid binding protein 7 is a molecular marker in adenoid cystic carcinoma of the salivary glands: implications for clinical significance. Transl Oncol. 7(6):780-7. doi: 10.1016/j.tranon.2014.10.003.
Guinney J, Dienstmann R, Ferté C, Friend S, McCormick F. 2014 Social interactomes for enabling research communities. Cancer Discov. 4(11):1265-8. doi: 10.1158/2159-8290.CD-14-0774.
Phuchareon J, van Zante A, Overdevest JB, McCormick F, Eisele DW, Tetsu O. 2014 c-Kit expression is rate-limiting for stem cell factor-mediated disease progression in adenoid cystic carcinoma of the salivary glands. Transl Oncol. 7(5):537-45. doi: 10.1016/j.tranon.2014.07.006. eCollection 2014.
Sos ML, Levin RS, Gordan JD, Oses-Prieto JA, Webber JT, Salt M, et al. 2014 Oncogene mimicry as a mechanism of primary resistance to BRAF inhibitors. Cell Rep. 8(4):1037-48. doi: 10.1016/j.celrep.2014.07.010. Epub 2014 Aug 7.
Kashiyama T, Oda K, Ikeda Y, Shiose Y, Hirota Y, Inaba K, et al. 2014. Antitumor activity and induction of TP53-dependent apoptosis toward ovarian clear cell adenocarcinoma by the dual PI3K/mTOR inhibitor DS-7423. PLoS One 9(2):e87220. doi: 10.1371/journal.pone.0087220. eCollection 2014.
Salt MB, Bandyopadhyay S, McCormick F. 2014. Epithelial-to-mesenchymal transition rewires the molecular path to PI3K-dependent proliferation. Cancer Discov 4(2):186-99. doi: 10.1158/2159-8290.CD-13-0520. Epub 2013 Dec 3.
Stephen AG, Esposito D, Bagni RK, McCormick, F. 2014. Dragging Ras back in the ring. Cancer Cell 25(3):272-81. doi: 10.1016/j.ccr.2014.02.017.
Holderfield M, Lorenzana E, Weisburd B, Lomovasky L, Boussemart L, Lacroix L, et al. 2014. Vemurafenib cooperates with HPV to promote initiation of cutaneous tumors. Cancer Res 74(8):2238-45. doi: 10.1158/0008-5472.CAN-13-1065-T. Epub 2014 Feb 12.
Holderfield M, Deuker M, McCormick F, McMahon M. 2014. Targeting RAF kinases for cancer therapy: BRAF-mutated melanoma and beyond. Nature Rev Cancer 14(7):455-67. doi: 10.1038/nrc3760.
Yuan TL, Fellmann C, Lee CS, Ritchie CD, Thapar V, Lee LC, et al. 2014. Development of siRNA payloads to target KRAS-mutant cancer. Cancer Discov 4(10):1182-97. doi: 10.1158/2159-8290.CD-13-0900. Epub 2014 Aug 6.
Thai M, Graham NA, Braas D, Nehil M, Komisopoulou E, Kurdistani SK, McCormick F, Graeber TG, Christofk HR 2014. Adenovirus E4ORF1-induced MYC activation promotes host cell anabolic glucose metabolism and virus replication. Cell Metab 19(4):694-701. doi: 10.1016/j.cmet.2014.03.009.
2013
Young A, Lou D, McCormick F. 2013. Oncogenic and wild-type Ras play divergent roles in the regulation of mitogen-activated protein kinase signaling. Cancer Discov 3(1):112-23. doi: 10.1158/2159-8290.CD-12-0231. Epub 2012 Oct 25.
Holderfield M, Merritt H, Chan J, Wallroth M, Tandeske L, Zhai H, et al. 2013. RAF inhibitors activate the MAPK pathway by relieving inhibitory autophosphorylation. Cancer Cell 23(5):594-602. doi: 10.1016/j.ccr.2013.03.033.
Lyons J, Bastian BC, McCormick, F. 2013. MC1R and cAMP signaling inhibit cdc25B and delay cell cycle progression in melanoma cells. Proc Natl Acad Sci USA 110(34):13845-50. doi: 10.1073/pnas.1201917110. Epub 2013 Aug 1.
Nan X, Collisson EA, Lewis S, Huang J, Tamguney TM, Liphardt JT, McCormick F, Gray JW, Chu S. 2013. Single-molecule superresolution imaging allows quantitative analysis of RAF multimer formation and signaling. Proc Natl Acad Sci USA 110(46):18519-24. doi: 10.1073/pnas.1318188110. Epub 2013 Oct 24.
Nehil M, Paquette J, Tokuyasu T, McCormick F. 2014. High mobility group box 1 promotes tumor cell migration through epigenetic silencing of semaphoring 3A. Oncogene 33(44):5151-62. doi: 10.1038/onc.2013.459. Epub 2013 Nov 11.
Timmerman LA, Holton T, Yuneva M, Louie RJ, Padro M, Daemen A, et al. 2013. Glutamine sensitivity analysis identifies the xCT antiporter as a common triple-negative breast tumor therapeutic target. Cancer Cell 24(4):450-65. doi: 10.1016/j.ccr.2013.08.020. Epub 2013 Oct 3.
Yuan TL, McCormick F. 2013. Killing tumors by keeping ras and PI3’ kinase apart. Cancer Cell 24(5):562-3. doi: 10.1016/j.ccr.2013.10.015.
2012
Shoji K, Oda K, Kashiyama T, Ikeda Y, Nakagawa S, Sone K, et al. 2012. Genotype-dependent efficacy of a dual PI3K/mTOR inhibitor, NVP-BEZ235, and an mTOR inhibitor, RAD001, in endometrial carcinomas. PLoS One 7(5):e37431. doi: 10.1371/journal.pone.0037431. Epub 2012 May 25.
Stowe IB, Mercado EL, Stowe TR, Bell EL, Oses-Prieto JA, Hernández H, Burlingame AL, McCormick F. 2012. A shared molecular mechanism underlies the human rasopathies Legius syndrome and Neurofibromatosis-1. Genes Dev 26(13):1421-6. doi: 10.1101/gad.190876.112.
2011
Rauen KA, Banerjee A, Bishop WR, Lauchle JO, McCormick F, McMahon M, et al. 2011. Costello and cardio-facio-cutaneous syndromes: Moving toward clinical trials in RASopathies. Am J Med Genet C Semin Med Genet 157C(2):136-46. doi: 10.1002/ajmg.c.30294. Epub 2011 Apr 14.
McCormick F. 2011. Cancer therapy based on oncogene addiction. J Surg Oncol 103(6):464-7. doi: 10.1002/jso.21749.
McCormick F. 2011. Mutant onco-proteins as drug targets: successes, failures, and future prospects. Curr Opin Genet Dev 21(1):29-33. doi: 10.1016/j.gde.2010.12.002. Epub 2011 Jan 12.
Gysin S, Salt M, Young A, McCormick F. 2011. Therapeutic strategies for targeting ras proteins. Genes & Cancer 2(3):359-72. doi: 10.1177/1947601911412376.